Best Answer: Hi Jennifer! You absolutely need LOTS of water before you fly and during the flight. It's crucial to stay hydrated, as that will keep your skin and body refreshed. *This is not relevant to your question, but important: make sure you take precaution and get any necessary shots a few weeks before your trip so they have time to do their magic. You don't want to get to Africa and get sick. You also don't want to contract something on the plane. Planes are flying Petri dishes! Talk to your physician and ask what to do for your health prior to, and during your trip. Now, back to the eyes. I definitely recommend the Kiehl's Eye De-Puffer. It feels cool and tingly when you apply it, and it really does seem to refresh my eyes. Make sure you get plenty of sleep before you fly and on the flight when you can. Sleeping with your head elevated can help reduce puffiness. While you're flying, ask the flight attendant for a cold, wet washcloth. It may not be available, but it's worth asking. You could take a cloth in your carry-on bag and ask for a cup of ice or some water. A cold compress seems to help my eyes. If that won't work you can always try going to the sink in the bathroom on the plane and in the airport and splash a few rounds of cold water on your face. Eye puffiness is the result of excess fluid around the eyes, so one thing you can do is gently massage around your eyes. In the area that is your eye socket, both under the brow and below the eyes where the "bags" are, if you press on them, you can feel little tiny grooves in the bone around your eyes. If you rub very gently, all the way around the eyes, you can work some of that fluid back in through the grooves. Cut back on salt and high-sodium foods. Snack on bananas, which help alleviate puffiness. Eat cabbage or drink cranberry juice, which helps get rid of some of the excess fluid. You can also put refrigerated tea bags on your eyes, as they are astringent. I hope some of these help you. Have a fantastic trip!