Over-Night Biological Peel

A potent, overnight peel for smoother, more even skin.
  • Helps to gently renew skin, leaving texture softer, more even, and vibrant after first use
  • With continued use, helps reduce the look of pore size and ameliorate the effects of free-radical and photo-damage
  • Non-comedogenic, oil-free, and dermatologist tested
  • May be used by all skin types
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"It's extremely powerful but so gentle on my skin-- by morning, my skin is softer, smoother and clearer."

Roshini, Kiehl’s Insider

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How to Apply:
-Cleanse skin thoroughly prior to application
-Apply face peel at night, avoiding immediate eye area, and allow to dry on skin
-Leave on overnight and remove with warm water in the morning
-Use three times per week, or more as needed

HEPES, or Hydroxyethylpiperazine Ethane Sulfonic Acid, is a chemical buffer which is widely used in cell culture to maintain physiological pH. This amino-sulfonic derivative helps to improve skin and limits roughness.

SO-di-em HI-ah-loor'uh'nayt

Sodium Hyaluronate is the sodium salt of Hyaluronic Acid. It is used as a moisturizing agent, viscosifier and emulsifier. It forms a transparent film on the skin which has a soothing and lubricating action. It is a powerful humectant as it is capable of binding 1,800 times its own weight in water. See also: Hyaluronic Acid.


An enzyme activator naturally present in the surface layer of the skin (epidermis), Urea accelerates the natural process of cell renewal through the exfoliation of dead surface skin cells. The ingredient has a water binding effect in the top layers of the skin thus acting as a natural moisturizing agent in human skin.

Browse 53 questions and 119 answers
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Why did you choose this?
Kiehl's Since 1851 Store
i like how it feels in my skin
Jocelyn A on Apr 11, 2015
I am buying this product for myself and my teenage son. I am hoping it gives my skin a brightness and his skin some relief from acne.
Marianne G on Apr 2, 2015
To smoothen my complexion and get rid of acne and acne-related imperfections.
Sara P on Apr 6, 2015
friend recommended
Denise H on Mar 24, 2015
Is this product safe to use during pregnancy?
A shopper on May 31, 2012
Best Answer: Maybe Kiehls can answer this question since so many of us think its a good question and it hasnt been answered...
Reply · Report · Farida H on Apr 19, 2014
Is this product safe for Rosecea skin?
A shopper on Jun 24, 2012
can we layer serums on with this as well, and if so does serum go first for does the peel go first?
A shopper on Feb 18, 2013
Best Answer: I would suggest using the peel first and solo for a few days. Once you see how much exfoliation occurs, apply your serum every 2 days. You want your skin to fully exfoliate (peel) and follow-up with the serum on a clear facial palette - the serum will be more effective.
Reply · Report · GERTRUDE W. R on Mar 4, 2013
Can this product be used instead of Retin A? Also is it safe to use while pregnant?
A shopper on Apr 7, 2012
Is this safe for women that are breastfeeding?
A shopper on May 14, 2014
Over-Night Biological Peel
Over-Night Biological Peel
Powerful Wrinkle Reducing Cream
Powerful Wrinkle Reducing Cream
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Can you use the Overnight Biological Peel after using the Epidermal Re-Texturizing Micro-Dermabrasion? Would it help with the effectiveness, or would it be too much for your skin?
Wanrawee M on Dec 10, 2014
Over-Night Biological Peel
Over-Night Biological Peel
Epidermal Re-Texturizing Micro-Dermabrasion
Epidermal Re-Texturizing Micro-Dermabrasion
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Is it safe to use during breastfeeding?
A shopper on Mar 30, 2014
Best Answer: This product has several types of paraben in it as preservatives. Of course lots of things we use nowadays have preservatives and the concentration level is safe but I guess it would be good to not use it that much since you don't want to pass on chemicals to your infant
Reply · Report · Deborah W on Oct 1, 2014
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Is this good for acne prone skin?
A shopper on Dec 10, 2013
Best Answer: I can only speak for myself but yes. It even helps accelerate the healing process of breakouts.
Reply · Report · Karlo E on Dec 11, 2013
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Is this product safe for acne prone skin? I have some hyperpigmentation left over from acne whose appearance I would like to improve. I was wondering if this would help with those.
A shopper on Apr 12, 2014
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is it ok to use it with the dark spot corrector and midnight recovery or should i use this every other night and then use the two the other nights?
A shopper on Apr 19, 2012
Best Answer: My understanding is that the peel should be used by itself; leave it on overnight and then wash it off in the morning with a warm, damp face cloth.
Reply · Report · Donna W on Apr 22, 2012
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Do you put this on before or after moisturizer? Or do not put on moisturizer when you use this product?
Gaby S on Jan 17, 2013
Best Answer: No mouisturizer. As it's a peel I want it to do it's work. So I cleanse and put it on then sleep. When I wake up I just rinse it off and moisturize then. I use it about every other night and use my moisturizer on the other nights.
Reply · Report · Sarah G on Jan 17, 2013
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i have acne sequel (acne marks) in my face, will this treatment help my sken to get even?
Monica Perez on Mar 6, 2013
Best Answer: No. Although this product will gently remove the top layer of your skin, it will not penetrate deep enough to offer you an even tone that will erase those acne marks.
Reply · Report · Kimberly R on Mar 6, 2013
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The peel does not dry on my skin, instead it leaves a sticky film. Is it because I used too much? How many pumps should you use?
A shopper on Mar 16, 2013
Best Answer: It is sticky, but I love it. My face does not feel sticky in the morning, and after I wash it it looks so refreshed!! I use 3-4 pumps nightly.
Reply · Report · kathy m on Apr 11, 2013
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When you apply this, does it soak into your skin or leave a sticky film on your face all night? If it leaves a film how do you avoid getting it on sheets/pillows?
Amber on Jul 8, 2014
Best Answer: it does not absorb in, nor does it leave a sticky film. I guess the best way to describe it is that it's like a moist dry. If you wait for about a half hour before you lay down you shouldn't have any problem. I love this product and I do notice a difference.
Reply · Report · Elyse G on Jul 8, 2014
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Are you supposed to shake before use?
A shopper on Oct 24, 2013
Best Answer: I didn't.
This product has not been making a significant change to my skin, perhaps you should shake it? I am oily skin with acne problem, this one kinda feel too heavy for me.
Reply · Report · Boya D on Oct 25, 2013
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so I don't have to put any moisturizers, just this?
A shopper on May 2, 2012
Best Answer: No moisturizer, only the peel.
Reply · Report · Mimi N on May 2, 2012
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Is this product okay to use with people with acne?
KP013 on Jun 15, 2014
Best Answer: Yes. It's never affected my skin with breakouts. It's very gentle.
Reply · Report · krista g on Jun 15, 2014
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Can you use with retin a?
A shopper on Apr 22, 2013
Best Answer: Do not combine! Retin A is a prescribed topical medicine. It also works by sloughing off layers of the skin however at a much higher rate. Combining the 2 or even switching back and forth may cause inflammation along with frustration. I understand the desire to exfoliate, you may want to use a mild facial cleanser in the mornings that contains AHA or BHA along with a soft facial brush or pad using circular outward motions. always remember to hydrate and use suncreen. if your skin needs to calm down i do recommend the calendula/marigold toner that kielhs has.
Reply · Report · Jamy K on May 2, 2013
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Would I be able to use your product or would it cause any reaction if use it with Retin A or Glycolic Acid?
Every so often I switch off to different treatments and I was given a bottle of Biological peel as a gift.
Thank you, JAM
Janina on Mar 4, 2013
Best Answer: Janina M. your question is a very good one. I can relate because I do the same - switch off to different treatments. I think Kiehls ONB Peel is very effective. It is not as harsh as Retin A but does create a good peel which allows exfoliation.
Reply · Report · GERTRUDE W. R on Mar 4, 2013
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Does this product work like a facial masque?
Nicole W on May 9, 2012
Best Answer: Not exactly. It doesn't harden, and it's not something you have to peel off. In fact I leave it on and don't wash it off.
I love this product. It makes my skin firm, gets rid of uneven color and brown spots, and gives my complexion a glow.
I am 63 years old and I know by now there is no miracle in a bottle :-)
but this product does make my skin look great. And it doesn't have harmful chemicals in it.
I use it pretty much everyday.
I think you will like it and I hope it works for you.
xo xo
Reply · Report · Valorie H on May 9, 2012
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Do you put moisturizer on after using it?
A shopper on Mar 20, 2014
Best Answer: I do not - this is a very concentrated product and I prefer to let it do its thing without "diluting" it with another product on top of it. A little bit goes a long way. I use about 4 pumps, rub together on my fingertips and that's enough for my whole face. It feels thick at first, but will eventually soak in.
Reply · Report · Stacey V on Mar 20, 2014
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Can you wear a moisturizer with this?
A shopper on Apr 5, 2014
Best Answer: I apply it after my moisturizer every other evening. Love this product!
Reply · Report · Christine C on Apr 5, 2014
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how often do you recommend using this product and should your face peel or be flaky after use the following morning? Thanks
Sher R on Jul 14, 2012
Best Answer: I don't have a frequency recommendation, except to follow the directions on the label and to pay attention to how your skin responds; I use this peel about once a week because I often use glycolic acid products at night, which are pretty strong.

No, your face should not peel or be flaky in the morning. When I wash the product off, my skin feels smooth and supple.
Reply · Report · Mimi N on Jul 14, 2012
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If I sleep on my side and/or stomach, will this be effective, or will my pillow steal most of it?
Brett F on Aug 15, 2014
Best Answer: Hi Brett,

If you apply it and lay on your stomach right after, then your pillow will definitely steal most of it. Otherwise, you can apply it an wait a few minutes to give your skin a chance to absorb it.

Reply · Report · Luis S on Aug 15, 2014
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I have used this twice now and I do not "peel"... Isn't it supposed to exfoliate? Shouldn't I see some type of peeling of the dead top layer?
Ginia on Sep 21, 2014
Best Answer: Virginia, if your skin actually peeled after using this project, that would be more damaging/harsh than the project should be. I think the peeling your thinking about is like after having a sun burn, which is damaged skin coming off. Even rubbing your hands together produces an exfoliating effect, without visibly seeing the skins cells coming off, but it is.
Reply · Report · Jennifer G on Sep 21, 2014
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I have extremely dry skin...the flakey kind. I have used numerous peels and masks to try to rid myself of these embarrassing flakes, in addition to some of the most expensive moisturizers on the market. Will this peel help eliminate the flakes or make it worse? LeeAnn
A shopper on Jun 14, 2013
Best Answer: The first week when u use it, it may show some effects. But after one week, nothing special would happen. N it's a bit sticky, so when u sleep, u may feel a bit uncomfortable. But everybody's skin is different. So this is just my own situation. I actually stop using it, n try other products.
Reply · Report · Peishan (KC) C on Jun 14, 2013
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can u use just under eyes? says not to get close to eyes but not sure if thats ok
A shopper on Jun 5, 2012
Best Answer: I would not use any "peel" (neither biological nor chemical) product on the under-eye area. The skin under the eye is much thinner and therefore more fragile and sensitive. If you're looking for a good under-eye anti-ageing product, you might try Line-Reducing Eye Brightening Concentrate or Midnight Recovery Eye.
Reply · Report · Erin H on Jun 6, 2012
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Will it brighten dark spots?
A shopper on Mar 30, 2015
Best Answer: It didn't brighten my dark spots but my skin was pretty heavily damaged. It definitely improved skin text texture, got rid of pimples overnight, and gave my skin a healthy-looking shine.
Reply · Report · Sarah E on Mar 31, 2015
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Does this product contain urea from real
A shopper on Mar 20, 2015
Best Answer: I would suspect not. Everything I have read says that the urea used in cosmetic is a synthetic version.
Reply · Report · Victoria F on Mar 23, 2015
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First time I will use this product over night biological peel ..just want to know you just put this only at night?
A shopper on Jan 29, 2014
Best Answer: I believe it is recommended to use at night, largely because it is most likely on the skin longer with good effect. I used during the day with less intense effect.
Reply · Report · Leesa T on Feb 2, 2014
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Do you use a moisturizer on top of this serum? Thank you for any input!
Victoria F on Dec 2, 2013
Best Answer: This is NOT a serum. You use overnt, then WASH OFF before moisturizing.
Reply · Report · linda z on Dec 31, 2013
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I am 55 years old. Use the Kiehls facewash then follow with the Midnight Recovery Concentrate. If I were to use the Over Night Biological Peel (3 times a week) would I still follow with the Recovery Concentrate and moisturizer or nothing else other than the peel?
Maureen G on Oct 14, 2013
Best Answer: I would still use both after. the peel seems to make your skin accept the moisturizer better.
Reply · Report · rosetta m on Oct 14, 2013
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Can I put this on right after the microdermabrashion?
A shopper on Oct 2, 2013
Best Answer: Yes - especially since the microdermabrasion can irritate and dry the skin (depending on how long and forcibly you use the dermabrasion, what temperature the water is, etc) the Midnight Oil Concentrate helps the skin recover and remain moist afterward.
Reply · Report · Lawrence W on Nov 25, 2013
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How can i used this peel with my cc dark spot solution?
A shopper on May 22, 2013
Best Answer: The C.C. Dark Spot Solution should be applied after you use the toner and before you apply moisturizer or lotion. The Over-Night Biological Peel probably is best used as a stand-alone--AFTER you cleanse your face. The peel is to be worn over-night and then washed off in the morning. What I do: cleanse, toner, over-night peel. Since I only use the over-night peel once per week or two weeks, not using the C.C. Dark Spot Solution that one night is no big deal (especially since I use the dark spot solution twice daily).
Reply · Report · Angela W on Jun 21, 2013
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does this product contain my alcohol?
A shopper on May 2, 2013
Best Answer: Not the form of ethyl any other significant amounts. If you are concerned about drying still continue to use your moisturizer after the treatment has had a chance to absorb. Remember to use sunscreen, you will become sensitive and do not use a facial scrub or AHA treatment within the next few days.
Reply · Report · Jamy K on May 2, 2013
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I use benzoyl peroxide in my regiment due to my acne and i tend to break out whenever I don't use it at night. Is there a way of applying BP and then putting the over-night biological peel on?
Richard on Mar 13, 2013
Best Answer: I wouldn't recommend using both products at once as part of your nightly regimen, you may tend to over stimulate your oil/sebum production and then may lead to nice rosy patches where you didn't want to draw attention, your face. use the peel on clean skin, allow to absorb, follow with your moisturizer. think of it a a vacation day/night from your BP. If you're like me and experience oily skin I also recommend changing your pillow case frequently. I personally use cotton or linen and change them every 2 days so i'm not sleeping on the same surface. also my face cloth i change 3 times a week.
Reply · Report · Jamy K on May 2, 2013
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does this help with crepy arm skin???
Laurie on Feb 24, 2013
Best Answer: No
Reply · Report · Eddie S on Apr 11, 2013
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Is it possible to try the Over-night Biological Peel on my sun-damaged arms? Also, I had used the hand cream called"Unusually Rich--But Not Greasy At All--Hand Cream, with SPF 10. Now, I cannot locate this at Kiehl"s at all.
donamarie M on Jul 4, 2012
Best Answer: I can't imagine doing any harm except to your wallet since the arms are a much bigger surface to cover than the face. it's a good product but no miracle for sun damaged skin. like many biological peel products, results largely disappear with continued sun exposure because they partially remove the uppermost layer of skin to reveal newer layers than can be more vulnerable to UV rays.
Reply · Report · Leesa T on Jul 6, 2012
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What is the procedure to use the peel? Apply and leave on over night? Scrub it off? Just how does it work?
Mary W on Jun 16, 2012
Best Answer: You apply and leave it on overnight. I usually do full coverage on my face. It doesn't dry like a mask which is good. So you still have the ability to eat etc without it feeling like it's dried up. Next morning, you just use a facial cleanser to remove it. After using it for a while, you'll notice some affected spots on your skin get better.
Reply · Report · Daniel L on Jun 16, 2012
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Does it help on acne scars?
Camilla B on Jun 6, 2012
Best Answer: I bought this about a month ago, and continue using it for about 2 weeks. For me, it does not really help with my acne scars, and neither fit my skin type (oily combination), I still have pretty much a lot of problems with my skin.
Reply · Report · Boya D on Jun 7, 2012
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Can you use the overnight Biological Peel with the Clearly Corrective Dark Spot Solution?

If you get a rash from these products what can you use to heal it?
Khali B on Mar 16, 2015
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Does work on milia (clogged pores, but not acne)?
jean f on Mar 9, 2015
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if I want to use both Over-Night Biological Peel and Midnight Recovery Concentrate, in which order should I use them?
A shopper on Feb 14, 2015
Over-Night Biological Peel
Over-Night Biological Peel
Midnight Recovery Concentrate
Midnight Recovery Concentrate
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Is this product safe to use with benzoyl peroxide?
TM1210 on Dec 8, 2014
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Are the questions being answered by customers who use the product or a Kiels skin specialist? My question was about the other of layer in a night cream with or not
A shopper on Nov 23, 2014
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Does this have BHA or AHA in it?
Elizabeth S on May 30, 2014
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I received a couple samples of this peel. I used the entire sample pack on my face and found it to be sticky the whole night. Is that the recommended amount to be used each time? Just wanted to be sure before I buy a bottle of it.
Jesse T on Jan 23, 2014
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Can you use this if u have severe acne and post marks even though its start to heal?
A shopper on Jun 30, 2013
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How do i use over-night biological peel? I have lots of scars from pimples and I just ordered dark spots corrector serum and wanna peel it off too. I think if i apply both.It would be better and faster.
A shopper on Feb 4, 2013
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After you wash your skin when should you apply this, after the toner etc?...
A shopper on Oct 4, 2012
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I have the sample of this but im wondering if its ok to use it after i use the dark spot corrector and midnight recovery?
A shopper on Apr 12, 2012
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Does this product contain paragons?
Melissa on Jun 21, 2014
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We’re confident you will see healthier, revitalized skin in
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Kiehl’s Skincare is scientifically formulated to restore and strengthen the skin barrier for healthier, younger-looking skin. Our targeted treatments are powerful, yet safe preparations which act to correct and treat your specific skin needs and concerns.